A major study of annual screening (with ultrasound and CA125) for four years failed to show much of a benefit with screening. Over 75% of the cancers diagnosed were still Stage III or IV. This remains the big problem with ovarian cancer: symptoms are vague and by the time it's diagnosed it's usually in an advanced state. Mortality data is still lacking from this study published in the journal Obstetrics and Gynecology in April. A summary of the research can be found on the excellent Libby's H*O*P*E.